Effects of oxidative stress in response to mycotoxins in dairy cows
Reactive oxygen species (ROS) are normally neutralized by sufficient antioxidant levels in the cow. However, an imbalance between the production of ROS and defense ability of the cow to neutralize ROS causes oxidative stress.
Diseases that can cause significant economic losses in dairy herds, such as subclinical mastitis and ketosis, have been associated with increased markers of oxidative stress in the milk. For example, dairy cows with higher levels of somatic cell counts in milk also showed more signs of oxidative stress, as indicated by levels of malondialdehyde and dinitrophenylhydrazine.
Mycotoxins are known to increase oxidative stress. Therefore, they are also a factor, which can predispose dairy cows to subclinical mastitis and ketosis.
As cases of subclinical mastitis in dairy cows can cost on average $110/cow/year and ketosis $150/cow/year, mycotoxins can be a culprit in significant economic losses in dairy herds.
References
Mostert et al 2018. Estimating the economic impact of subclinical ketosis in dairy
cattle using a dynamic stochastic simulation model, Animal, p 145-154
Ruegg 2005. Premiums, Production and Pails of Discarded Milk How Much Money Does
Mastitis Cost You? University of Wisconsin
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