Effects of oxidative stress in response to mycotoxins in dairy cows

Reactive oxygen species (ROS) are normally neutralized by sufficient antioxidant levels in the cow. However, an imbalance between the production of ROS and defense ability of the cow to neutralize ROS causes oxidative stress.

Diseases that can cause significant economic losses in dairy herds, such as subclinical mastitis and ketosis, have been associated with increased markers of oxidative stress in the milk. For example, dairy cows with higher levels of somatic cell counts in milk also showed more signs of oxidative stress, as indicated by levels of malondialdehyde and dinitrophenylhydrazine.

Mycotoxins are known to increase oxidative stress. Therefore, they are also a factor, which can predispose dairy cows to subclinical mastitis and ketosis.

As cases of subclinical mastitis in dairy cows can cost on average $110/cow/year and ketosis $150/cow/year, mycotoxins can be a culprit in significant economic losses in dairy herds.


Mostert et al 2018. Estimating the economic impact of subclinical ketosis in dairy
cattle using a dynamic stochastic simulation model, Animal, p 145-154

Ruegg 2005. Premiums, Production and Pails of Discarded Milk How Much Money Does
Mastitis Cost You? University of Wisconsin

Abuelo et al 2015 The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation 

Santos and Fink-Gremmels 2014. Mycotoxin syndrome in dairy cattle: characterization and intervention results

Andrei et al 2016. Interrelationships between the content of oxidative markers, antioxidative status, and somatic cell count in cow’s milk. Czech J. Anim. Sci., 61, 2016 (9): 407–413

Watch a short video about this topic at the end of the Monday mycotoxin report below

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How to take your birds from doing great to agile for consistent efficiency

In today’s world layer and broiler producers need to be highly responsive to quickly changing market needs (i.e. agile) and at the same time continuously increase efficiency. This also increases the requirement for robustness and the ability to adapt to nutritional and environmental challenges in birds for reliable performance. Nutritional approaches for gut agility are enabling more consistent efficiency in a sustainable manner.

Genetic progress is alive. Hens have longer and more productive laying cycles and broilers are growing faster and more efficiently. What has not changed is that management of birds is still key to maximize efficiency, health and welfare. To empower birds to live up to new genetic heights, producers need to pay extra attention to nutrition throughout the lifetime of each flock. Nutritional stressors in the diet, such as dietary changes, reduced nutrient digestibility, endotoxins, antinutritional factors and mycotoxins, can undermine consistency in performance in response to diets. Depending on the presence or absence of those stressors the same diet can differ in cost-effectiveness. These stressors are often not easy to control for the nutritionist and are part of the reality that animals are facing in modern production systems.

Ability to adapt

Ability to adapt to different climates, management systems and environmental challenges are sought after traits in today’s birds for commercial production. The ability to adapt to nutritional stressors will have an impact on consistency of performance and efficiency of birds. Hence, what we are looking for in birds is not much unlike a key trait of successful companies in today’s business environment: agility. Agility in this context meaning the capacity to adapt to changes and challenges quickly and efficiently to maintain high performance, efficiency and profitability. We never know what is around the corner, but the ability to adapt will make or break us. It determines sustained success. Taking birds from doing great to agile is a step towards greater robustness, efficiency and performance consistency in birds. This advancement will to some extent be achieved by genetic selection programs, but the faster way is to support it by nutritional means. Nutritional approaches for gut agility in the bird, are designed to empower the bird to adapt to nutritional challenges more efficiently and minimize the negative impact on performance consistency.

Feed efficiency

Reducing antibiotic growth promotors in animal feed calls for the development of new strategies to improve feed efficiency in poultry production systems. Genetic research provides a picture of the basis of feed efficiency at the cellular level. Oxidative stress turned out to be a cellular activity affecting feed efficiency. The studies showed that birds with higher feed efficiency had better mitochondrial function that included less mitochondrial reactive oxygen species (ROS) production and less oxidation of proteins.

More recent studies confirmed that feeding a phytogenic formula containing certain phenolic terpenes and flavonoids to broilers significantly increased the antioxidative capacity
in breast tissue, thigh, liver tissue and certain parts of the gut. There was also a significant positive relationship between antioxidative capacity and feed efficiency. Parameters for ROS scavenging activity, activity of antioxidative enzymes and reduced lipid peroxidation were significantly improved in those tissues. This indicates that feeding strategies including certain phytogenic compounds for increased antioxidative capacity could support feed efficiency in broilers. Improved antioxidative capacity in birds also implies that birds will experience less oxidative stress, which again can reduce inflammatory responses and hence improve energy efficiency. Heat stress, high stocking density and
mycotoxins are known factors which normally lead to increased oxidative stress. Hence, birds with improved antioxidative capacity will also be more resistant to those type of stressors.

Greater laying persistence

By 2020 layers are expected to lay 500 eggs in a single laying cycle of 100 weeks. Genetic companies working towards this goal have been selecting traits that increase the laying persistency of hens. Their motivation for this has been the need to be able to produce eggs in a more sustainable way. In June this year, Germany already reported the first commercial layer flock achieving 500 eggs in 100 weeks in Dekalb laying hens.

Benefits of genetic selection for improved laying persistence and stability in egg quality can only be realized if they are matched by improvements in hen nutrition. There are three important areas that come to mind, when it comes to supporting laying persistence by nutritional means:

1) Careful management of feed/nutrient intake around start of lay and in early laying period
2) Maintaining organs that are important for egg production healthy, e.g. liver
3) Minimizing common stress reactions such as oxidative stress, inflammatory responses and reduction in feed intake to maintain birds healthy and efficient

High performing hens with longer laying cycles are more prone to metabolic disturbances and susceptible to free radical (ROS) damage. This can be justified by the intense metabolism demanded for continuous egg production and environmental stress. Adding certain plant extracts to diets has been shown to improve the antioxidant status in laying hens and can be used to prevent oxidative stress. This then also has the potential to prevent fatty liver hemorrhagic syndrome (FLHS). Fatty liver-hemorrhagic syndrome is a typical liver damage caused by oxidative stress. Laying hens tend to exhibit fatty liver due to the damage caused by free radicals and excessive fat in the liver.

Adding a product including phytogenic components with antioxidative power and designed for gut agility to the late laying period of a commercial ISA Brown parent layer flock, improved the persistency in lay compared to birds on a control diet.

Agile by nutrition

Nutritional concepts designed to support the bird’s capacity to adapt to nutritional challenges and live up to its performance potential, increase the agility of the bird particularly under situations of increased stress. Overall, they are a sustainable alternative to help reduce the use of antibiotics in poultry diets, whilst maintaining robust and efficient birds for consistency in the cost-effectiveness of diets at high performance levels.


by Gwendolyn Jones, published in International Poultry Production, August 2018, page 7